Tissues derived from reprogrammed Wharton's jelly stem cells of the umbilical cord as a platform to study gestational diabetes mellitus.

Chiou Mee Kong,Subramanian Arjunan,Shu Uin Gan,Biswas Arijit,Bongso Ariff,Chui-Yee Fong

Stem Cell Research（2020）

引用 2|浏览22

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摘要

•hWJSC-iPSCs is an ideal platform to study the pathogenesis of maternal hyperglycemia on the fetus.•GDM-iPSCs had decreased potential towards differentiation into insulin-producing cells (IPCs).•IPCs differentiated from GDM-iPSCs had a lower insulin secretion to glucose challenge.

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关键词

Gestational diabetes mellitus,Induced pluripotent stem cells,Reprogramming,Wharton’s jelly stem cells,Pancreatic cells

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