Characteristics of Aged Ischemic Stroke Patients Indicative of Cardioembolism

Matsuzono Kosuke,Mashiko Takafumi,Ozawa Tadashi,Miura Kumiko,Suzuki Masayuki,Furuya Kohei,Ozawa Misato,Anan Yuhei,Shimazaki Haruo,Koide Reiji,Tanaka Ryota,Kameda Tomoaki,Fujimoto Shigeru

Journal of Thrombosis and Thrombolysis（2020）SCI 4区

Jichi Medical University | Shin-Oyama City Hospital

Cited 5|Views22

Abstract

The treatment of ischemic stroke has recently witnessed dramatic developments. However, there are limited data on ischemic stroke characteristics in aged patients. As part of the South Tochigi Acute Ischemic Stroke Registry, we prospectively enrolled 636 consecutive acute ischemic stroke patients (within 7 days after the onset) who were ≥ 60 years of age and who were admitted to two independent institutes from April 1, 2016 to February 28, 2019. We analyzed three groups divided by age: early-aged (60–69 years), middle-aged (70–79 years), and oldest-aged (≥ 80 years). From the 636 subjects, 194 were early-aged, 215 were middle-aged, and 227 were oldest-aged. There were significant differences in the ischemic stroke subtypes in each aging group (p < 0.01). The proportion of cardioembolism was 22.2% in early-aged, 27.4% in middle-aged, and 41.4% in the oldest-aged patients. The proportion of patients with a modified Rankin Scale of 0–2 at 1 year after onset decreased to 42.2% in middle-aged and 17.8% in oldest-aged with cardioembolic ischemic stroke. The proportion of patients receiving anticoagulation therapy before admission was 25.6% (36.7% of atrial fibrillation [AF]) in early-aged, 39.0% (52.3% of AF) in middle-aged, and 18.1% (21.0% of AF) in oldest-aged patients (p < 0.001). Our study reports characteristics of clinical ischemic stroke in an aging population. The assessment of cardiogenic embolism is important for an aging population.

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Key words

Aged,Ischemic stroke,Cardioembolism,Anticoagulant therapy,Gender

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