Crystal Structures of Human PAICS Reveal Substrate and Product Binding of an Emerging Cancer Target
Journal of biological chemistry/The Journal of biological chemistry（2020）
关键词
de novo purine biosynthesis,nucleotide metabolism,cancer target,rational drug design,carboxyaminoimidazole ribonucleotide (CAIR),N-succinylcarboxamide-5-aminoimidazole ribonucleotide (SAICAR),phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthetase (PAICS),prostate cancer,structural biology,purine,cancer therapy,drug design,nucleoside,nucleotide biosynthesis
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