Continuous Renal Replacement Therapy and Survival in Acute Liver Failure: A Systematic Review and Meta-Analysis

•Ammonia is a key driver of cerebral edema in acute liver failure.•Cerebral edema is a big contributor to mortality in acute liver failure.•Continuous renal replacement therapy has been shown to reduce ammonia levels.•This study found continuous renal replacement therapy improves overall survival.•This study found continuous renal replacement therapy improves transplant-free survival.