Nigral and ventral tegmental area lesioning induces testicular and sperm morphological abnormalities in a rotenone model of Parkinson's Disease.

Ifeoluwa O Awogbindin,Isaac A Adedara,Philip A Adeniyi,Alberta E Agedah,Bisola F Oyetunde,Precious D Olorunkalu,Emmanuel Ogbuewu,Inioluwa A Akindoyeni,Yusuf E Mustapha,Oluwatoyin G Ezekiel,Ebenezer O Farombi

Environmental Toxicology and Pharmacology（2020）

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摘要

•Nigral and VTA rotenone infusion mediate sperm and testicular abnormalities.•The lesion compromised testicular tight junctions and germinative elements.•The brain lesion enhanced testicular caspase-3 but decreased SRY and GADD45 g signal.•The lesion caused testicular oxidative damage and reduced acetylcholinesterase activity.•The lesion was associated with reduced testosterone but FSH was not affected.

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关键词

Parkinson’s disease,Testicular pathology,Nigrostriatal degeneration,Sperm abnormalities,Neural-hypothalamic-testicular circuit,Acetylcholinesterase

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