Manipulation of beta-adrenergic receptor in pressure-overloaded murine hearts mimics adverse and reverse cardiac remodeling.

Koichi Nishimura,Masanori Asakura,Shinichi Hirotani,Yoshitaka Okuhara,Manabu Shirai,Yoshiyuki Orihara,Yuki Matsumoto,Yoshiro Naito,Naoto Minamino,Tohru Masuyama,Masaharu Ishihara

Biochemical and Biophysical Research Communications（2020）

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摘要

Transverse aortic constriction (TAC) has been widely used to create pressure overload induced heart failure in mice. However, this conventional model has some limitations such as low reproducibility and long creation period of cardiac failure.

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关键词

Novel mouse model of heart failure,Combination of pressure overload and betaadrenergic receptor stimuli,Adverse cardiac remodeling,Cardiac reverse remodeling,Heart failure,RNA-Seq

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