Caffeine increases peripheral fatigue in low- but not in high-performing cyclists

The influence of cyclists' performance levels on caffeine-induced increases in neuromuscular fatigue after a 4-km cycling time trial (TT) was investigated. Nineteen cyclists performed a 4-km cycling TT 1 h after ingesting caffeine (5 mg.kg(-1)) or placebo (cellulose). Changes from baseline to after exercise in voluntary activation (VA) and potentiated 1Hz force twitch (Q(tw.pot)) were used as markers of central and peripheral fatigue, respectively. Participants were classified as "high performing" (HP, n = 8) or "low performing" (LP, n = 8) in accordance with their performance in a placebo trial. Compared with placebo, caffeine increased the power, anaerobic mechanical power, and anaerobic work, reducing the time to complete the trial in both groups (p < 0.05). There was a group versus supplement and a group versus supplement versus trial interaction for in which the postexercise reduction was greater after caffeine compared with placebo in the LP group (Q(tw.pot)= -34% +/- 17% vs. -21% +/- 11%, p = 0.02) but not in the HP group (Q(tw.pot) = -22% +/- 8% vs. -23% +/- 10%, p = 0.64). There was no effect of caffeine on VA, but there was a group versus trial interaction with lower postexercise values in the LP group than in the HP group (p = 0.03). Caffeine-induced improvement in 4-km cycling TT performance seems to come at the expense of greater locomotor muscle fatigue in LP but not in HP cyclists. Novelty Caffeine improves exercise performance at the expense of a greater end-exercise peripheral fatigue in low-performing athletes. Caffeine-induced improvement in exercise performance does not affect end-exercise peripheral fatigue in high-performing athletes. High-performing athletes seem to have augmented tolerance to central fatigue during a high-intensity time trial.