Tea saponins as natural stabilizers for the production of Hesperidin nanosuspensions.

Jiaying Long,Jiawen Song,Xumin Zhang,Mao Deng,Long Xie,Linlin Zhang,Xiaofang Li

International Journal of Pharmaceutics（2020）

引用 38|浏览14

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摘要

•Tea saponins have the potential to stabilize nanosuspensions at low concentration.•Tea saponins and lactose can prevent agglomeration of hesperidin solid nanocrystals.•Dissolution of hesperidin nanosuspensions was superior to that of physical mixture.

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关键词

Nanosuspensions,Tea saponins,Hesperidin,Stabilizers,Poorly soluble drug,Cryoprotectants

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