Enhancing in vivo oral bioavailability of cajaninstilbene acid using UDP-glucuronosyl transferase inhibitory excipient containing self-microemulsion.
Colloids and Surfaces B: Biointerfaces（2020）
Abstract
•SME-1 improved in vitro release, cellular uptake, and transport.•SME-1 decreased the production of phase II metabolite, CSA-G.•Inhibitory SME-1resulted in significantly higher oral bioavailability.•Enhanced oral bioavailability attributed to the inhibition of glucuronidation.
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Key words
CSA,UGT,GI,SME,op-10,FBS,MEM,PDI,Caco-2,AP,BL,Papp,SPF,SD,AUC
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