MTL-CEBPA, a Small Activating RNA Therapeutic Upregulating C/EBP-α, in Patients with Advanced Liver Cancer: A First-in-Human, Multicenter, Open-Label, Phase I Trial. Debashis Sarker , Ruth Plummer , Tim Meyer , Mikael H. Sodergren , Bristi Basu , Cheng Ean Chee , Kai-Wen Huang , Daniel H. Palmer , Yuk Ting , T. R. Jeff Evans , Duncan R. C. Spalding , Madhava Pai , Rohini Sharma , David J. Pinato , James Spicer , Sarah Hunter , Vineet Kwatra , Joanna P. Nicholls , David Collin , Robert Nutbrown , Helen Glenny , Sonia Fairbairn , Vikash Reebye , Jon Voutila , Stephanie Dorman , Pinelopi Andrikakou , Peter Lloyd , Steve Felstead , Jenni Vasara , Robert Habib , Chris Wood , Pal Saetrom , Hans E. Huber , David C. Blakey , John J. Rossi , Nagy Habib pubmed（2023）
摘要
Dose escalation flow chart. DLT - dose limiting toxicity, MTD - maximum tolerated dose
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关键词
Liver Cancer, RNA methylation, Treatment, Methylation
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