Targeted tumor therapy by autophagy of nanoparticles.

Autophagy is an important biological mechanism that regulates the growth, death and energy metabolism of eukaryotic cells. It is also an active and evolutionarily conservative catabolic process to maintain homeostasis during cell stress response and cell survival. Autophagy maintains the body's stability by degrading damaged proteins, organelles, cytoplasm and invasive microorganisms. Studies have found that autophagy also has a significant impact on the occurrence and development of tumors. Simultaneously, nanoparticles (NPs) can induce autophagy in cells, and the level of autophagy can be regulated by the synthesis design of NPs. Therefore, the study of the regulation of autophagy by NPs is of great significance for the treatment of cancer autocorrelation.