Chemical Constituents from the Thorns of Gleditsia Sinensis and Their Cytotoxic Activities

A new aromatic glycoside (1) and a new natural product, neolignan (2), along with twenty-three known compounds (3-25), were isolated from the thorns of Gleditsia sinensis. According to the spectroscopic analyses (IR, UV, HRESIMS, NMR and ECD), the structures of isolates were elucidated. Herein, compounds 4, 6-8, 10-13, 15, 16, 18, 20, 23 were isolated from the plant of G. sinensis for the first time. Moreover, compounds 4, 6, 15 and 24 showed cytotoxic effects on human ovarian cancer (SKOV-3) cells with IC50 values of 24.83 +/- 4.90, 48.86 +/- 9.11, 80.13 +/- 5.62, 15.38 +/- 2.21 mu M, respectively. [GRAPHICS] .