Impact of Weight Loss with Laparoscopic Sleeve Gastrectomy on Left Ventricular Diastolic Function: a Prospective Study

Purpose The present study purposed to investigate the effects of weight loss with LSG on echocardiographic parameters of diastolic dysfunction in subjects with morbid obesity. Methods Sixty-one subjects undergoing LSG for standard indications were enrolled. All subjects underwent a physical examination, electrocardiography, and transthoracic echocardiography before and 6 months after the LSG. Peak early diastolic velocity (E), deceleration time (DT), and peak late diastolic velocity (A) were measured from the transmitral flow signal. Peak early ( e ′) diastolic mitral annular velocity was measured at the two acquisition sites (basal septal and basal lateral) using the tissue Doppler recordings. Results A significant improvement was observed in echocardiographic measures of the diastolic function including E / A ratio, E / e ′ ratio, DT, and isovolumic relaxation time (IVRT) from baseline to the postoperative 6 months. Left atrial volume index (LAVI) reduced from 30.3 ± 3.9 ml/m 2 to 28.0 ± 3.3 ml/m 2 ( p < 0.001). In addition, interventricular septum diameter (IVSD) significantly decreased from 11.3 ± 1.3 mm to 10.2 ± 1.1 mm ( p < 0.001). The change in BMI was significantly correlated with the improvements in DT ( r = 0.334, p = 0.012), E / e ′ ( r = 0.440, p = 0.001), E / A ( r = − 0.317, p = 0.017), and IVRT ( r = 0.348, p = 0.008). Conclusion LSG leads to a significant improvement in echocardiographic measures of the left ventricular diastolic function in subjects with obesity. Our findings also show that LSG leads to a reverse remodeling indicated by the decrease in interventricular septum thickness and left atrial volume index in this population.