Severe widespread actinic damage and squamous cell carcinoma: could hydrochlorothiazide be implicated? A report of two cases

British Journal of Hospital MedicineVol. 81, No. 3 Case ReportsSevere widespread actinic damage and squamous cell carcinoma: could hydrochlorothiazide be implicated? A report of two casesAmrita Randhawa, Grant WylieAmrita RandhawaCorrespondence to: Amrita Randhawa; E-mail Address: [email protected]Department of Dermatology, Queen Elizabeth University Hospital, Glasgow, UKSearch for more papers by this author, Grant WylieDepartment of Dermatology, Queen Elizabeth University Hospital, Glasgow, UKSearch for more papers by this authorAmrita Randhawa; Grant WyliePublished Online:23 Mar 2020https://doi.org/10.12968/hmed.2019.0242AboutSectionsView articleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareShare onFacebookTwitterLinked InEmail View articleReferencesBoffa RJ, Constanti M, Floyd CN, Wierzbicki AS; Guideline Committee. Hypertension in adults: summary of updated NICE guidance. BMJ. 2019 Oct 21;367:l5310. https://doi.org/10.1136/bmj.l5310 Crossref, Medline, Google ScholarDTB Team. MHRA drug safety update: hydrochlorothiazide and non-melanoma skin cancer. Drug Ther Bull. 2019;57(5):70. https://doi.org/10.1136/dtb.2019.000023 Crossref, Medline, Google ScholarJensen AØ, Thomsen HF, Engebjerg MC et al.. Use of photosensitising diuretics and risk of skin cancer: a population-based case-control study. Br J Cancer. 2008;99(9):1522–1528. https://doi.org/10.1038/sj.bjc.6604686 Crossref, Medline, Google ScholarPedersen SA, Gaist D, Schmidt SA et al.. Hydrochlorothiazide use and risk of nonmelanoma skin cancer: a nationwide case-control study from Denmark. J Am Acad Dermatol. 2018;78(4):673–681. https://doi.org/10.1016/j.jaad.2017.11.042 Crossref, Medline, Google ScholarPedersen SA, Schmidt SA, Hölmich LR et al.. Hydrochlorothiazide use and risk for Merkel cell carcinoma and malignant adnexal skin tumors: a nationwide case-control study. J Am Acad Dermatol. 2019;80(2):460–465. https://doi.org/10.1016/j.jaad.2018.06.014 Crossref, Medline, Google ScholarShin D, Lee ES, Kim J et al.. Association between the use of thiazide diuretics and the risk of skin cancers: a meta-analysis of observational studies. J Clin Med Res. 2019;11(4):247–255. https://doi.org/10.14740%2Fjocmr3744 Crossref, Medline, Google Scholar FiguresReferencesRelatedDetailsCited byHydrochlorothiazide: A savior to the heart or a foe to the skin?Annals of Medicine and SurgeryHydrochlorothiazide/amiloride23 January 2021 | Reactions Weekly, Vol. 1839, No. 1 2 March 2020Volume 81Issue 3ISSN (print): 1750-8460ISSN (online): 1759-7390 Metrics History Published online 23 March 2020 Published in print 2 March 2020 Information© MA Healthcare LimitedPDF download