The Role of Glutamate Neurotransmission in Mismatch Negativity (MMN), A Measure of Auditory Synaptic Plasticity and Change-detection

•Mismatch negativity (MMN) is a change-detection response.•MMN generation requires intact sensory memory processes and synaptic plasticity.•MMN responses are reduced by antagonists of the NMDA receptor.•Recent studies have also shown that other neurotransmitters may play a role in MMN.