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Serologic Detection of Middle East Respiratory Syndrome Coronavirus Functional Antibodies

Nisreen M A Okba,Ivy Widjaja,Wentao Li,Corine H GeurtsvanKessel,Elmoubasher A B A Farag,Mohammed Al-Hajri,Wan Beom Park,Myoung-Don Oh,Chantal B E M Reusken,Marion P G Koopmans,Berend-Jan Bosch,Bart L Haagmans

Emerging infectious diseases（2020）

Cited 27|Views59
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Abstract
We developed and validated 2 species-independent protein-based assays to detect Middle East respiratory syndrome coronavirus functional antibodies that can block virus receptor-binding or sialic acid-attachment. Antibody levels measured in both assays correlated strongly with virus-neutralizing antibody titers, proving their use for serologic confirmatory diagnosis of Middle East respiratory syndrome.
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antibody
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