Transcriptome-wide piRNA profiling in human brains for aging genetic factors.

Qiao Mao,Longhua Fan,Xiaoping Wang,Xiandong Lin,Yuping Cao,Chengchou Zheng,Yong Zhang,Huihao Zhang,Rolando Garcia-Milian,Longli Kang,Jing Shi,Ting Yu,Kesheng Wang,Lingjun Zuo,Chiang-Shan R Li,Xiaoyun Guo,Xingguang Luo

Jacobs journal of genetics（2019）

引用 4|浏览56

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摘要

We conclude that piRNAs might play a potential role in determining the years of survival of humans. The underlying mechanisms might involve the suppression of transposable elements (TEs) and expression regulation of aging-associated genes.

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关键词

Alzheimer’s disease,aging,brain,gene expression,piRNA,transposable elements (TEs),years of survival

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