Effects of the long and short isoforms of TIPE3 on the growth and metastasis of gastric cancer.

Jie-Fang Gao,Hong Zhang,Jian Lv,Yue-Ying Fan,Dou Feng,Ling Song

Biomedicine & Pharmacotherapy（2020）

引用 6|浏览5

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摘要

•The expression of TIPE3 decreased in gastric cancer.•The patients with high TIPE3 expression have a low overall survival rate.•TIPE3 isoforms promoted GC proliferation and metastasis both in vitro and in vivo.•TIPE3 isoforms promoted growth and metastasis of GC cells vis PI3K/Akt pathway.

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关键词

TIPE3 variants,Gastric cancer,Proliferation,Metastasis,PI3K/Akt signaling pathway

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