Lansoprazole Enhances the Antidiabetic Effect of Dapagliflozin in Fortified Diet-Fed Streptozotocin-Treated Diabetic Rats.

Noha M. Gamil,Mai A. Abd El Fattah,Maha A. E. Ahmed,Yousreya A. Maklad,Amina A. Gamal el Din,Nihad Eid

Journal of biochemical and molecular toxicology（2020）

Cited 4|Views8

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Abstract

Dapagliflozin (DAPA) is used for treating type 2 diabetes, whereas lansoprazole (LPZ) is used as a traditional antiulcer drug. The present study investigated the possible antidiabetic effects of LPZ on fortified diet-fed streptozotocin (FDF/STZ)-induced insulin-resistant diabetic rats. On the basis of the current results, it can be concluded that LPZ could be used as an add-on drug along with the conventional treatment for T2D as it showed beneficial effects in the current experimental model of insulin resistance.

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Key words

dapagliflozin,fortified diet,Glut-2 expression,insulin resistance,lansoprazole

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