Nerolidol inhibits the LOX-1 / IL-1β signaling to protect against the Aspergillus fumigatus keratitis inflammation damage to the cornea.

Hua Yang,Qian Wang,Lin Han,Xuejiao Yang,Wenyi Zhao,Leyu Lyu,Limei Wang,Haijing Yan,Chengye Che

International Immunopharmacology（2020）

引用 19|浏览9

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摘要

•Nerolidol protected the corneas from infection by inhibiting the growth of Aspergillus fumigatus.•Nerolidol played a protective role to corneal transparency in mouse A. fumigatus keratitis.•Nerolidol impaired LOX-1/IL-1β signaling in mice corneas and HCECs infected by A. fumigatus.

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关键词

Keratitis,Aspergillus fumigatus,Nerolidol,LOX-1,IL-1β

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