Miniaturization of liquid chromatography coupled to mass spectrometry 1. Current trends on miniaturized LC columns
TRAC-TRENDS IN ANALYTICAL CHEMISTRY(2020)
摘要
Over the last decade, the use of miniaturized columns in liquid chromatography (LC) has seen intense growth in a wide range of research areas. This report brings an overview of the current developments and applications of miniaturized columns in LC, focused on the type of columns used. Following a short introductory section on some theoretical aspects, the fundamental bases on their design and fabrication, new stationary phases and incorporated materials, performance evaluation/characterization, main advantages, and recent applications of filled capillary and open tubular (OT) capillary columns are introduced and critically discussed. Prospects on the different types of miniaturized columns and their hyphenation with mass spectrometry (MS) reported in the last years are also introduced and discussed. (C) 2019 Elsevier B.V. All rights reserved.
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关键词
Miniaturized liquid chromatography,Particle packed capillary column,Monolithic capillary columns,Open-tubular columns,Wall coated open-tubular columns,Porous layer open tubular columns,Mass spectrometry
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