Role Of Circulating Myeloid-Derived Suppressor Cell (Mdsc) In Hodgkin Lymphoma (Hl) Patients: Prospective Study

Introduction. MDSC's are a heterogeneous population of bone marrow-derived myeloid progenitors including macrophages, granulocytes, dendritic cells and immature myeloid cells, which expand dramatically with tumour growth, and there are several clues have an important role in the disease progression. Recent studies have also highlighted interim PET as the most important prognostic factor for HL. The interim PET positivity may indicate that there is a reactive microenvironment promoting tumor cells survival. In this study we analyzed the prognostic significance of MDSC count together with PET in HL patients.