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EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex

Jessie Hao-Ru Hsu,Timothy Rasmusson,James Robinson,Fiona Pachl,Jon Read,Sameer Kawatkar,Daniel H. O'Donovan,Sharan Bagal,Erin Code,Philip Rawlins,Argyrides Argyrou,Ronald Tomlinson,Ning Gao,Xiahui Zhu,Elisabetta Chiarparin,Kelly Jacques,Minhui Shen,Haley Woods,Emma Bednarski,David M. Wilson,Lisa Drew,M. Paola Castaldi,Stephen Fawell,Andrew Bloecher

CELL CHEMICAL BIOLOGY（2020）

Cited 114|Views39
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Key words
proteolysis targeting chimeras (PROTACs),polycomb repressive complex 2 (PRC2),ubiquitin-mediated protein degradation,druggability,EED,EZH2,SUZ12
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