Fabrication and Characterization of Cobalt Hyaluronic Acid Nanostructure Via Gamma Irradiation for Improving Biomedical Applications

Aqueous dispersed cobalt hyaluronic acid nanostructure (CoHANs) was synthesized using cobalt ion (Co+2) as precursor and natural polysaccharide hyaluronic acid (HA) as stabilizing agent and gamma irradiation as reducing agent. The synthesized CoHANs are characterized by UV-Vis. spectroscopy, Dynamic light scattering (DLS), X-ray diffraction (XRD) and Fourier Transform Infrared spectroscopy (FT-IR). The morphology and surface appearance of CoHANs has been observed by SEM images. The particles size and shape of CoHANs were estimated by TEM images and was found to be 12.0 nm. XRD analysis of the CoHANs confirmed the formation of crystalline nanoparticles. The nucleation and growth mechanism of CoHANs was also discussed. The size of nanoparticles was found to be influenced by certain parameters such as the choice of stabilizer and cobalt ion concentration and the absorbed dose. The results indicated the CoHANs possesses high activity than cobalt ion and HA. The present study explored the positive role of CoHANs as an antitumor agent on different cell carcinoma in vitro. Excellent bactericidal spatially against pathogenic bacteria and fungicidal activity was shown by the CoHANs. (C) 2019 Elsevier B.V. All rights reserved.