Controlled Synthesis of Calcium Carbonate Nanoparticles and Stimuli-Responsive Multi-Layered Nanocapsules for Oral Drug Delivery

Calcium carbonate nanoparticles loaded with curcumin were modified by layer-by-layer to form stimuli responsive nanocapsules. In-vitro drug release at different pH conditions mimicking gastrointestinal transit showed that the design of the structures of the layers in the nanocapsules can be used to protect the drug in the stomach and release it in the intestine.