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Discovery and Optimization of Heteroaryl Piperazines As Potent and Selective PI3Kδ Inhibitors

Hua Zhou,Meredeth A. McGowan,Kathryn Lipford,Matthew Christopher,Xavier Fradera,David Witter,Charles A. Lesburg,Chaomin Li,Joey L. Methot, John Lampe,Abdelghani Achab,Lynsey Shaffer,Peter Goldenblatt,Sanjiv Shah,Alan Bass,Gottfried Schroeder,Dapeng Chen,Haoyu Zeng,Martin A. Augustin,Jason D. Katz

Bioorganic & medicinal chemistry letters（2020）

Cited 9|Views33
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Key words
Phosphoinositide 3-kinase delta,PI3K delta inhibitor,Structure-activity relationship,Parallel medicinal chemistry,Physicochemical properties
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