Translational Approach to Predicting the Efficacy of Maraviroc-Based Regimens As HIV Preexposure Prophylaxis

Nithya Srinivas,Mackenzie Cottrell,Kaitlyn Maffuid,Heather A. Prince,Julie A. E. Nelson,Nicole White,Craig Sykes,Evan S. Dellon,Ryan D. Madanick,Nicholas J. Shaheen,Daniel Gonzalez,Angela D. M. Kashuba

Antimicrobial agents and chemotherapy（2020）

Cited 7|Views61

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Abstract

Maraviroc-based regimens have been explored as preexposure prophylaxis (PrEP) against human immunodeficiency virus (HIV). In this study, we utilized mucosal tissue drug exposure data, combined with target concentrations generated in vitro , in a pharmacokinetic-pharmacodynamic analysis to predict the effects of drug combinations and adherence on PrEP efficacy. Mucosal tissue concentrations of maraviroc were measured in 24 healthy women.

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Key words

HIV,antiretroviral,translational medicine,dose response,population pharmacokinetics-pharmacodynamics,quantitative pharmacology,preexposure prophylaxis,maraviroc,tenofovir,emtricitabine

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