Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway.

Mathilde Prud'homme,Maxime Coutrot,Thibault Michel,Louis Boutin,Magali Genest,Françoise Poirier,Jean-Marie Launay,Bocar Kane,Satoshi Kinugasa,Niki Prakoura,Sophie Vandermeersch,Alain Cohen-Solal,Claude Delcayre,Jane-Lise Samuel,Ravindra Mehta,Etienne Gayat,Alexandre Mebazaa,Christos E Chadjichristos,Matthieu Legrand

JACC Basic to translational science（2019）

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摘要

Acute kidney injury is associated with increased risk of heart failure and mortality. This study demonstrates that acute kidney injury induces remote cardiac dysfunction, damage, injury, and fibrosis via a galectin-3 (Gal-3) dependent pathway. Gal-3 originates from bone marrow-derived immune cells. Cardiac damage could be prevented by blocking this pathway.

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