Crystal Structure of the Putative Cyclase IdmH from the Indanomycin Nonribosomal Peptide Synthase/polyketide Synthase.

Ieva Drulyte,Jana Obajdin,Chi H. Trinh,Arnout P. Kalverda,Marc W. van der Kamp,Glyn R. Hemsworth,Alan Berry

IUCRJ（2019）

引用 9|浏览29

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摘要

The crystal structure of IdmH from the biosynthetic gene cluster for indanomycin is presented. NMR data show that this enzyme binds its postulated product, indanomycin, and QM/MM modelling of the reaction strongly supports the view that IdmH catalyses indane-ring formation in indanomycin biosynthesis via a Diels–Alder reaction.

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关键词

polyketide biosynthesis,antibiotics,Steptomyces antibioticus,cycloaddition,crystal structure,protein crystallography,QM/MM reaction modelling,Diels-Alder reaction

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