The Construction of DNAzyme-based Logic Gates for Amplified Microrna Detection and Cancer Recognition.
Analyst (London 1877 Online)/Analyst(2019)
摘要
Benefiting from the simple DNAzyme and a duplex-specific nuclease, a series of microRNA-stimulated DNAzyme logic gates were rationally assembled for the highly accurate detection of multiple low-abundant microRNA biomarkers that correspond to the specific aberrant microRNA expression patterns of cancer tissues, thus showing a great potential in early diagnosis.
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