Brca1-Bard1: The Importance Of Being In Shape
MOLECULAR & CELLULAR ONCOLOGY(2019)
摘要
The breast cancer type-1 susceptibility protein (BRCA1) contributes to genome integrity through homologous recombinational DNA repair and by protecting stalled replication forks from nucleolytic degradation. We recently discovered that fork protection requires a conformational change of BRCA1 unimportant to homologous recombination repair, indicating separate roles for BRCA1 in these pathways.
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关键词
BRCA1, BARD1, PIN1, fork protection, isomerization, RAD51
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