Protective Effects of Olive Leaf Extract on Inflammatory Activation of Endothelial Cells

Background and Aims: Olive leaf extract (OLE) has been traditionally used due to its anti-inflammatory and anti-atherogenic effects. The mechanism through which OLE modulates atherogenesis is unclear. Serum amyloid A (SAA) is a major inflammatory mediator in humans linking inflammation and atherosclerosis. Our aim was to explore the antiinflammatory properties of OLE in the SAA-activated endothelial cells from the human coronary arteries (HCAEC), the most susceptible vascular site in atherosclerosis.