A Self-Assembled AMF-Responsive Nanoplatform Based on Pillar[5]arene and Superparamagnetic Nanoparticles for Controlled Release of Doxorubicin

An alternating magnetic field (AMF)-stimuli responsive nanodevice based on magnetic nanoparticles (MNP) functionalized with water-soluble carboxylate-substituted pillar[5] arene (CP[5] A), namely MNP-CP[5] A, as a multiplatform for cancer treatment has been designed. MNP-CP[5] A was loaded with doxorubicin (DOX), showing a loading capacity of 9.5 mg g(-1). The nanodevice demonstrated good colloidal stability, superparamagnetic behavior, and was capable to generate detectable heat in solution induced by AMF application. DOX release, monitored by ultraviolet-visible (UV-Vis) spectroscopy, was investigated by varying the temperature (37 and 45 degrees C) without AMF and in the presence of AMF (frequency (f) = 307 kHz, field amplitude (H) = 200 Oe, 45 degrees C) at pH = 7.4. Thermo-induced DOX release without AMF was 1.9% (1.8 mu g mL(-1)) and 2.3% (3.3 mu g mL(-1)) at 37, and 45 degrees C within 50 min, respectively. In an AMF DOX release increased to 5.7% (8.2 mu g mL(-1)) within 50 min. Therefore, MNP-CP[5] A-DOX works as a chemo-hyperthermia nanodevice.