Immune checkpoint inhibitor-induced sarcoidosis-like granulomas
International Journal of Clinical Oncology(2019)
摘要
Immune checkpoint inhibitors targeting the cytotoxic T lymphocyte-associated antigen-4 and programmed cell death-1 receptors have transformed the treatment of melanoma and other cancers. These therapies are associated with a number of side effects, including immune-related adverse events. Sarcoidosis-like granulomas (SLGs) are important immune checkpoint inhibitor-related reactions to recognize as SLGs can mimic disease progression and accordingly impact treatment decisions. We systematically review reports of immune checkpoint inhibitor-induced SLGs in cancer patients and discuss potential underlying pathophysiological mechanisms.
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关键词
Drug reactions, Melanoma, Immune checkpoint inhibitor, PD-1, CTLA-4, Sarcoidosis-like granuloma
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