Direct Benzylic Functionalization of Pyridines: Palladium-catalyzed Mono-Α-arylation of Α-(2-pyridinyl)acetates with Heteroaryl Halides
Chinese Chemical Letters/Chinese chemical letters(2020)
摘要
Herein,we report a Pd-catalyzedmono- α-arylationreactionforpyridinebenzylicfunctionalization.This approach serves as an efficient alternative to synthesize di-heteroaryl acetates in good yields and selectivities. Moreover, the method is applicable to heteroaryl substrate combinations, and exhibits great functional group tolerance. A streamlined protocol also enables the rapid synthesis of diheteroaryl ketones. The synthetic value was also demonstrated by scale-up experiments
更多查看译文
关键词
α-Arylation,Palladium,Heterocycles,Pyridines,Cross-coupling
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要