OP0177 ASSOCIATION BETWEEN METABOLIC SYNDROME AND KNEE STRUCTURAL CHANGE ON MRI: A 10.7-YEAR FOLLOW-UP STUDY

Background Metabolic syndrome (MetS) has been suggested a crucial role in the pathophysiology of osteoarthritis (OA); however, currently none of studies have examined the associations between MetS and structural changes on MRI. Objectives To describe the associations between MetS and its components and strucutral changes on MRI including knee cartilage volume (CV) loss and bone marrow lesion (BML) change over 10.7 years. Methods Longitudinal data on 435 participants (mean age 61 years, 50% of females) from a population-based cohort study were analysed. Blood pressure, glucose, triglycerides, and high-density lipoprotein (HDL) were collected. MetS was defined based on the National Cholesterol Education Program-Adult Treatment Panel III criteria. MRI of the right knee was performed to measure CV and BML. Radiographic knee osteoarthritis (ROA) was assessed by X-ray. Results 32% of participants had MetS and 60% had ROA. In multivariable analysis, the following were independently associated with medial tibial CV loss [MetS: β=-0.30%; central obesity: β=-0.26%; low HDL: β=-0.26% per annum]. MetS, hypertriglyceridemia and low HDL were also associated with higher risk of BML size increase in the medial compartment [MetS: relative risk (RR) 1.72, 95%CI 1.22-2.43; Hypertriglyceridemia: RR 1.43, 95%CI 1.01-2.02; low HDL: RR 1.67, 95%CI 1.18-2.36]. After further adjustment for central obesity, MetS and low HDL remained significant with both medial tibial CV loss and BML size increase. The number of components of MetS correlated with greater CV loss and BML size increase (both P for trend <0.05). There were no statistically significant associations in the lateral compartment. Conclusion MetS and low HDL are associated with medial compartment CV loss and BML worsening, suggesting that targeting MetS has the potential to prevent or slow structural change in knee osteoarthritis. Disclosure of Interests None declared