Distribution of transplantation-associated thrombotic microangiopathy (TA-TMA) and comparison between renal TA-TMA and intestinal TA-TMA: autopsy study.

Biology of Blood and Marrow Transplantation(2020)

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摘要
•We systemically evaluated transplantation-associated thrombotic microangiopathy (TA-TMA) in the largest number of autopsied patients.•The kidney and intestine were commonly affected by TA-TMA.•Many organs were initially histologically confirmed as TA-TMA sites.•The histologic overlap of renal and intestinal TA-TMA was rare at the autopsy.•Intestinal TA-TMA was more closely associated with a history of intestinal graft-versus-host disease.
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关键词
Hematopoietic stem cell transplantation,Thrombotic microangiopathy,Transplantation-associated thrombotic microangiopathy,Graft-versus-host disease,Autopsy
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