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CoCl 2 induced hypoxia enhances osteogenesis of rat bone marrow mesenchymal stem cells through cannabinoid receptor 2.

Menghan Zhang,Xinlian Shi, Jingxiang Wu,Yi Wang,Jian Lin,Ya Zhao,Huimin Li,Manman Ren,Rongdang Hu,Fen Liu,Hui Deng

Archives of Oral Biology（2019）

Cited 12|Views4
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Abstract
•CoCl2 induced osteogeneis of rBMSCs via MAPK pathways.•CoCl2 increased the mRNA and protein expressions of CB2 in rBMSCs.•Inhibition of CB2 attenuated CoCl2 induced osteogenesis of rBMSCs.•CoCl2-induced MAPK pathways could be inhibited by CB2 antagonizer.
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Key words
Hypoxia,Osteogenesis,Cannabinoid receptor,Bone marrow mesenchymal stem cells
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