Altered biochemical metabolism and its lateralization in the cortico-striato-cerebellar circuit of unmedicated bipolar II depression.

Shunkai Lai,Shuming Zhong,Yanyan Shan,Ying Wang,Guanmao Chen,Xiaomei Luo,Feng Chen,Yiliang Zhang,Shiyi Shen,Hui Huang, Yuping Ning,Yanbin Jia

Journal of Affective Disorders（2019）

引用 13|浏览11

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摘要

•Unmedicated patients with bipolar II depression had significantly lower NAA/Cr in the PWM, ACC, BG and cerebellum.•Unmedicated patients with bipolar II depression showed aberrant biochemical lateralization in the CSC circuit.•Lower NAA/Cr LI only in the BG and higher Cho/Cr LI in the cerebellum in healthy controls.

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关键词

Bipolar disorder,Cortico-striato-cerebellar circuit,Biochemical metabolism,Lateralization,Proton magnetic resonance spectroscopy,Cerebellum

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