Fast full-body reconstruction for a functional human RPC-PET imaging system using list-mode simulated data and its applicability to radiation oncology and radiology

Single-bed whole-body positron emission tomography based on resistive plate chamber detectors (RPC-PET) has been proposed for human studies, as a complementary resource to scintillator-based PET scanners. The purpose of this work is mainly about providing a reconstruction solution to such whole-body single-bed data collection on an event-by-event basis. We demonstrate a fully three-dimensional time-of-flight (TOF)-based reconstruction algorithm that is capable of processing the highly inclined lines of response acquired from a system with a very large axial field of view, such as those used in RPC-PET. Such algorithm must be sufficiently fast that it will not compromise the clinical workflow of an RPC-PET system. We present simulation results from a voxelized version of the anthropomorphic NCAT phantom, with oncological lesions introduced into critical regions within the human body. The list-mode data was reconstructed with a TOF-weighted maximum-likelihood expectation maximization (MLEM). To accelerate the reconstruction time of the algorithm, a multi-threaded approach supported by graphical processing units (GPUs) was developed. Additionally, a TOF-assisted data division method is suggested that allows the data from nine body regions to be reconstructed independently and much more rapidly. The application of a TOF-based scatter rejection method reduces the overall body scatter from 57.1 that a 300-ps FWHM RPC-PET scanner allows for the production of a reconstructed image in 3.5 minutes following a 7-minute acquisition upon the injection of 2 mCi of activity (146 M coincidence events). We present for the first time a full realistic reconstruction of a whole body, long axial coverage, RPC-PET scanner. We demonstrate clinically relevant reconstruction times comparable (or lower) to the patient acquisition times on both multi-threaded CPU and GPU.