Eight-day Inpatient Directly Observed Therapy for Antiretroviral Therapy (ART) Failure: A Tool for Preventing Unnecessary ART Changes and Optimizing Adherence Support

Nicole E. Winchester,Frank Maldarelli,Yolanda Mejia,Nicola Dee,Robin Dewar,Elizabeth Laidlaw,Safia S. Kuriakose,Pamela Stoll,Michael Proschan,H. Clifford Lane,Alice K. Pau

Clinical infectious diseases/Clinical infectious diseases (Online University of Chicago Press)（2019）

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摘要

Eight-day inpatient directly observed therapy confirmed nonadherence as the major cause of virologic failure for 9 (45%) of 20 highly treatment-experienced persons with human immunodeficiency virus, extensive antiretroviral drug resistance, and high self-reported adherence rates, preventing unnecessary regimen changes.

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关键词

antiretroviral therapy,viral failure,adherence,directly observed therapy,drug resistance

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