Eps4.02 Whole-genome Sequencing Reveals That Genetic Variations Predict Effectiveness of Vitamin D Supplementation in Young Children with Cystic Fibrosis

exacerbations (PEx).New airway clearance techniques (ACTs) adapted to individual needs are still being sought to achieve the best effect of airway clearance.The primary aim of this study was to evaluate the efficacy of Simeox -a new ACT in subjects with CF who were hospitalized due to PEx.Methods: CF Patients aged 10-18 admitted to hospital and requiring intravenous (IV) antibiotic therapy due to PEx were allocated consecutively (1:1) to Simeox arm or classical CP arm (without Simeox).Patients performed spirometry and multiple breath nitrogen washout (N 2 MBW) for Lung Clearance Index (LCI) assessment on admission and prior to discharge.Results: Fourty eight CF patients were included in the study: 24 treated with Simeox and 24 using usual CP.In both groups the spirometry parameters increased significantly after IV antibiotic therapy.Significant improvement in MEF 25 was observed only in patients treated with Simeox ( p < 0.01).A similar trend was observed towards lowering LCI ratio in both.No side effect was observed for each therapy.Drainage with Simeox was not painful for any of the patients and about 80% of them did not feel any fatigue.All patients felt comfortable and >80% learned quickly the use of new ACT.Conclusion: Spirometry parameters increased significantly in CF patients treated for PEx with IV antibiotic therapy and intensive CP.Simeox may improve the drainage of the central and peripheral airways.This new ACT was safe, well-tolerated method of CP and can be considered an option in treatment of PEx.