Closed-Loop Phase-Locked Electrical Stimulation Alters Low Frequency Coherence In A Fear Regulation Circuit

Brain connectivity may depend on the oscillatory synchrony of local field potential (LFP) between regions. However, clinical exploitation of this knowledge is limited by the lack of established paradigms to manipulate brain synchrony. For fear-related disorders, fronto-amygdalar connections are particularly important. This work describes a method to alter oscillatory synchrony (coherence) in fronto-amygdalar circuits in rodents.