Potential antidiabetic zinc(II) complexes of novel 5-oxo-2-thioxopyrrolidine derivatives synthesized via an unprecedented reaction

Saya Kawano,Yutaka Yoshikawa,Akihiro Kato,Shoko Higashi, Kyohei Mitani,Hiroyuki Yasui,Yoichi Habata,Shunsuke Kuwahara,Kaname Sasaki,Ryota Saito

Tetrahedron Letters（2019）

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摘要

•New 5-oxo-2-thioxopyrrolidines were synthesized through a novel reaction.•Zinc(II) complexes with the new ligands showed marked antidiabetic activity.•Lipophilicity of complexes is important to control the antidiabetic activities.

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关键词

5-Oxo-2-thioxopyrrolidine,Zinc(II) complex,Insulin-mimetic activity,Antidiabetic agent

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