Mitochondrial Pyruvate Import is a Metabolic Vulnerability in Androgen Receptor-Driven Prostate Cancer

David A. Bader,Sean M. Hartig,Vasanta Putluri,Christopher Foley,Mark P. Hamilton,Eric A. Smith,Pradip K. Saha,Anil Panigrahi,Christopher Walker, Lin Zong,Heidi Martini-Stoica,Rui Chen,Kimal Rajapakshe,Cristian Coarfa,Arun Sreekumar,Nicholas Mitsiades,James A. Bankson,Michael M. Ittmann,Bert W. O’Malley,Nagireddy Putluri,Sean E. McGuire

Nature metabolism（2018）

Cited 109|Views62

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Key words

Mitochondrial Pyruvate Carrier (MPC),Integrated Stress Response (ISR),On Oxidative Phosphorylation (OXPHOS),Reverse Phase Protein Array (RPPA),The Cancer Genome Atlas (TCGA)

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