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排名必读论文期刊顶会热点AI 简史溯源树小脉星探人才迁徙塔尖人才国防情报追踪开源工具智慧手语
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Pazopanib regresses a doxorubicin-resistant synovial sarcoma in a patient-derived orthotopic xenograft mouse model.

Kentaro Igarashi,Kei Kawaguchi,Tasuku Kiyuna,Kentaro Miyake,Masuyo Miyake,Scott D Nelson,Tara A Russell,Sarah M Dry,Yunfeng Li,Norio Yamamoto,Katsuhiro Hayashi,Hiroaki Kimura,Shinji Miwa,Takashi Higuchi,Shree Ram Singh,Hiroyuki Tsuchiya,Robert M Hoffman

Tissue and Cell（2019）

引用 4|浏览14
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摘要
•Synovial sarcoma is an aggressive subgroup of soft tissue sarcoma.•PAZ was significantly more effective than TEM and GEM + DOC.•PAZ significantly regressed the tumor volume.•PDOX model can identify effective therapy and ineffective drugs.
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关键词
Synovial sarcoma,Patient-derived orthotopic xenograft,PDOX,Precision medicine,Nude mice,Individualized therapy,Pazopanib
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