Advanced Glycation End Products Impaired Voltage-Gated K Plus Channel On Rat Coronary Smooth Muscle Cells By Activating Nf-Kb Signaling Pathway

Advanced glycation end products (AGEs) are well recognized pathogenic mediators in diabetes which could promote diabetic vasculopathy. Voltage-gated K+ (Kv) channels take responsibility for vasodilation in coronary arteries. The underlying mechanisms by which AGEs impaired Kv channels in rat