Effect of different emitter types on the production of nanofibrous tubular structures: Thickness uniformity and productivity

This contribution focuses on the effects of electrospinning process on the homogeneity of nanofibrous tubular structures caused by different emitters. Six types of emitters were used for the production of nanofibrous tubes. For all, the electric potential and the electric field were simulated. The quality of the produced tubes was verified by scanning electron microscopy, contact measurement of thickness and by a new digital image processing method based on transillumination. The analysis of the spun samples proved that the quality and therefore the parameters of the prepared tubes are significantly influenced by the choice of an emitter and its configuration. The use of the five-needle and needleless emitters resulted in a tenfold increase in production, however, image analysis revealed major thickness inhomogeneities. The highest thickness homogeneity and a high repeatability of the spinning process were achieved by using a moving double-needle emitter. The results will find use especially in the research of small-diameter vascular replacements and other applications in the field of tissue engineering requiring highly uniform tubular grafts. (C) 2019 Author(s).