Suppression of heme oxygenase-1 protein as potential target in ovarian cancer treatment

Arturas Sukovas,Vaidotas Cesna, Julius Bartasius,Aldona Jasukaitiene,Giedrius Barauskas,Ruta Jolanta Nadisauskiene,Zilvinas Dambrauskas,Saulius Paskauskas,Antanas Gulbinas

European Journal of Obstetrics & Gynecology and Reproductive Biology（2019）

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摘要

Introduction: Intraperitoneal chemotherapy and regional hyperthermia (HIPEC) are used to treat peritoneal carcinomatosis caused by ovarian cancer. Overexpression of heat shock protein heme oxygenase-1 (HO-1) in cancer cells contributes to cellular resistance against chemotherapy. There is no sufficient data about the role of HO-1 in ovarian cancer treatment.

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cancer

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