Kidney nanotoxicity studied in human renal proximal tubule epithelial cell line TH1

Monika Sramkova, Katarina Kozics,Vlasta Masanova, Iveta Uhnakova,Filip Razga, Veronika Nemethova,Petra Mazancova,Lucyna Kapka-Skrzypczak, Marcin Kruszewski,Marta Novotova, Victor F. Puntes,Alena Gabelova

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2019）

引用 18|浏览23

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摘要

•TH1 cells were exposed to inorganic NPs under continuous medium flow rate.•Only Fe3O4NPs (>700 μg/ml) induced a slight cytotoxicity after 24 h exposure.•None of the NPs increased the level of DNA strand breaks and oxidative DNA damage.•Fe3O4NPs were the most efficiently taken up while TiO2NPs the least one.•Phagocytosis/macropinocytosis is probably in involved in the uptake of NPs.

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关键词

Inorganic nanoparticles,Human renal proximal tubule cells,Comet assay,TEM analysis,AAS analysis,ICP-MS

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